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Complete information for CD47 gene (Protein Coding), CD47 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium 2019-09-11 · Moreover, high CD47 expression was associated with several clinicopathological parameters including TNM stage, histological grade, ER status, PR status and recurrence. However, high CD47 expression was not an independent and significant prognostic factor for DFS in a multivariate analysis. Lack of CD47 expression promotes a markedly accelerated development of spontaneous AIHA in the autoimmune-prone nonobese diabetic mice and results in increased sensitivity to experimental AIHA induced by both IgG1 and IgG2a anti-RBC monoclonal autoantibodies in nonautoimmune C57BL/6 mice. 19 We have previously suggested that, since CD47 is expressed on virtually all cells in the host, but not 2020-07-16 · Also, CD47 expression was increased in disseminated tumoral cells in control DLBCL xenograft animals, as well as in peripheral blood lymphoma cells compared with lymph node tumoral cells from NHL patients (although note peripheral blood and lymph node cells were not harvested from the same patients), further supporting a role for CD47 in the dissemination of B-NHL tumor cells .
Expression of CD47 (IAP, MER6, OA3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity. CD47 expression is decreased on the surface of erythrocytes in obese subjects.
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion
NX_Q08722 - CD47 - Leukocyte surface antigen CD47 - Expression. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.
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Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. CD47, an integrin-associated protein (IAP), is a universally expressed member of the immunoglobulin superfamily that plays a critical role in self-recognition. Recently, CD47 was recognized an immune checkpoint molecule. Lee et al.
Abstract CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a "don't eat me" signal, which can prevent cancer cells from immune clearance. Integrin-associated protein (CD47) is ubiquitously expressed on the surface of cells and functions as an identifier of self.
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PDF) Systematic screening of soluble expression of antibody . Kim Nilsson bild.
CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues.
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2021-04-04 · While CD47 expression on circulating AML blasts has been shown to be a negative prognostic marker for a very defined population of AML patients with NK AML, CD47 expression on AML BM blasts is not Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis Because CD47 binds SIRPα, regulation of CD47 expression might serve as a mechanism to control elimination or uptake of damaged or senescent RBCs. However, RBC CD47 expression is very narrowly distributed, with a negligible overlap between wild-type and heterozygous RBCs . Yet heterozygous RBCs showed normal survival in wild-type mice. 2021-03-25 · CD47 expression in normal pancreatic tissue (X100). b. representative image of CD47 expression in PanNET and adjacent normal pancreatic tissue (X200).