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Each pre-filled syringe contains 1.75 mg of bremelanotide (equivalent to 1.89 mg bremelanotide acetate) in 0.3 mL solution. The injection activates the melanocortin receptors, but scientists do not know how that leads to improved sexual desire. In clinical trials, Vyleesi was shown to be more effective than a placebo injection at improving sexual desire and reducing distress associated with sex. VYLEESI- bremelanotide injection Palatin Technologies-----HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use VYLEESI safely and effectively.

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2019-06-21 About Vyleesi™ (bremelanotide injection) Vyleesi is approved for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). The prefilled Vyleesi autoinjector is self-administered into a woman’s abdomen or thigh at least 45 minutes before anticipated sexual activity and can be taken at any time of day. About Vyleesi™ (bremelanotide injection) Vyleesi is approved for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). The prefilled Vyleesi autoinjector pen is self-administered into a woman’s abdomen or thigh at least 45 minutes before anticipated sexual activity and can be taken at any time of day. About Vyleesi™ (bremelanotide injection) Vyleesi is approved for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). About Vyleesi™ (bremelanotide injection) Vyleesi is approved for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).

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VYLEESI is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: 2019-06-21 · Vyleesi (bremelanotide) is a melanocortin receptor agonist for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Vyleesi is self-administered into a woman’s abdomen or thigh via prefilled autoinjector pen at least 45 minutes before anticipated sexual activity. It can be administered at any time of day. In its most recent form, Bremelanotide PT 141 is taken via a subcutaneous injection. The most appropriate sites for injection are where there are fat credits. Bremelanotide is the most often injected into the stomach region, thigh, and lower abdomen.
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1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone.

It has been tested in clinical trials as a treatment for both female hypoactive sexual desire disorder and acute hemorrhage. PT-141 is an agonist for the melanocortin-4 and melanocortin-1 receptors. PT 141 (Bremelanotide) Dosage A study was published in 2016 that tested its use on women.
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2 The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. 5 Bremelanotide was first described in the literature • VYLEESI is given as an injection under the skin (subcutaneous injection), in your thighs or stomach area (abdomen). • Inject VYLEESI at least 45 minutes before you think that you will begin sexual activity. • Conclusion: Bremelanotide is a subcutaneous injection that can be administered as needed approximately 45 minutes prior to sexual activity. Use the bremelanotide injection at least 45 minutes before sexual activity. Do not use more than 1 bremelanotide injection every 24 hours. Do not use more than 8 total injections within 1 month.