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Potent and selective ATM kinase inhibitor IC 50 s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively. 1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro. 2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to KU-55933A is a potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively). The addition of ATM inhibitor KU55933 to GRN163L/etoposide combination treatment increased cytotoxicity further, as observed in MCF-7 breast cancer cells. A previous model proposed that telomerase acts upstream from ATM activation and that telomerase inhibition prevents ATM activation through the structural regulation of chromatin . Find and order inhibitors and products like this ATM Kinase Inhibitor, KU-55933 on www.antibodies-online.com.
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Previous work suggested that ATM has temporally distinct functions in cells exposed to IR. KU-55933 (ATM Kinase Inhibitor) from Selleck Chemicals LLC. Product Specs; Item KU-55933 (ATM Kinase Inhibitor) Company Selleck Chemicals LLC; Catalog Number S1092; KU-55933 (ATM Kinase Inhibitor) KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50 / Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. 2009-11-10 · The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells. KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/K i of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription. Experimental Biology and Medicine, 2012.
Detection and Visualization of DNA Damage-induced Protein
ECM proteiner, eller inhibitorer för att undersöka ett brett spektrum av Recently, a specific inhibitor of the ATM kinase, KU-55933, was shown to radiosensitize human cancer cells. Herein, we report on an improved analogue of ATM-medierad fosforylering aktiverar den tumörundertryckande funktionen av In ATM inhibition experiments, cells were treated with 10 μ M KU55933 (a gift Skala bar, 10 μm.
Detection and Visualization of DNA Damage-induced Protein
Functional Studies - KU-55933, competitive ATM kinase inhibitor (ab120637) HepG2 cells were incubated at 37°C for 60 minutes with vehicle control (0 µM) and different concentrations of KU-55933 (ab120637). As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation. In the MTT assay, KU-55933 treatment suppressed cell proliferation by about 50% at concentration of 10 μM in MDA-MB-453 and PC-3 cells. Functional Studies - KU-55933, competitive ATM kinase inhibitor (ab120637) HepG2 cells were incubated at 37°C for 60 minutes with vehicle control (0 µM) and different concentrations of KU-55933 (ab120637). As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation. In the MTT assay, KU-55933 treatment suppressed cell proliferation by about 50% at concentration of 10 μM in MDA-MB-453 and PC-3 cells. KU-55933 (CAS 587871-26-9) is a potent, selective ATM kinase inhibitor, providing neuroprotection against H2O2-induced cell damage.
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Potent and selective ATM kinase inhibitor IC 50 s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively. 1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro. 2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to KU-55933A is a potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation.
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Examining the Dynamics of Cellular Adhesion and Spreading
The roles of ATM in stimulating glucose uptake, glycolysis, motility, and proliferation of cancer cells were demonstrated by knocking-down ATM in these cells. KU-55933 treatment also inhibits tumor growth and metastasis in vivo in mouse mammary tumors through inhibition of GLUT1 translocation and vimentin expression. Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin Mahvash Zakikhani1,2, Miguel Bazile2, Sina Hashemi2, Shiva ATM deficiency increases TMZ sensitivity, which suggests that ATM inhibitors may be effective TMZ sensitizing agents. In this study, the TMZ sensitizing effects of 2 ATM specific inhibitors were studied in established and xenograft-derived glioblastoma (GBM) lines that are inherently sensitive to TMZ and derivative TMZ-resistant lines. KU-55933是一种特异性的ATM激酶抑制剂，IC50值为13 nM[1]。ATM可以刺激Akt的Ser473磷酸化，介导胰岛素诱导的Akt充分激活。在血清饥饿后用胰岛素和IGF-I处理的MDA-MB-453和PC-3细胞中，作为ATM的抑制剂，KU-55933显著抑制Akt Ser473磷酸化的增加。 In this paper, we identified the nontoxic compound CP466722 as an inhibitor of ATM and offer a comparison to the established ATM inhibitor KU55933 ( 24).